Details

Autor(en) / Beteiligte

• Nadin, Alan
• López, José M. Sánchez
• Owens, Andrew P
• Howells, Dean M
• Talbot, Adam C
• Harrison, Timothy

Titel

New Synthesis of 1,3-Dihydro-1,4-benzodiazepin-2(2H)-ones and 3-Amino-1,3-dihydro-1,4-benzodiazepin-2(2H)-ones:  Pd-Catalyzed Cross-Coupling of Imidoyl Chlorides with Organoboronic Acids

Ist Teil von

• Journal of organic chemistry, 2003-04, Vol.68 (7), p.2844-2852

Ort / Verlag

Washington, DC: American Chemical Society

Erscheinungsjahr

2003

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A new approach to the synthesis of 1,4-benzodiazepines and 3-amino-1,4-benzodiazepines, which employs the Pd-catalyzed cross-coupling reaction of an imidoyl chloride with an organometallic reagent as the key step, is described. A five-step synthesis of a key intermediate is described and it is shown that in only four further steps (three couplings and a TFA-mediated BOC-deprotection) a wide variety of N1-, C3-amino-, C5-carbon-, or nitrogen-substituted 1,4-benzodiazepines can be synthesized.