Details

Autor(en) / Beteiligte

• Saah, Alfred J.
• Haas, David W.
• DiNubile, Mark J.
• Chen, Joshua
• Holder, Daniel J.
• Rhodes, Rand R.
• Shivaprakash, Malathi
• Bakshi, Kalpana K.
• Danovich, Robert M.
• Graham, Donald J.
• Condra, Jon H.

Titel

Treatment with Indinavir, Efavirenz, and Adefovir after Failure of Nelfinavir Therapy

Ist Teil von

• The Journal of infectious diseases, 2003-04, Vol.187 (7), p.1157-1162

Ort / Verlag

Chicago, IL: The University of Chicago Press

Erscheinungsjahr

2003

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• A prospective, open-label study was conducted to assess the response to indinavir, efavirenz, and adefovir in human immunodeficiency virus (HIV)–infected patients experiencing viral rebound while receiving therapy with nelfinavir-containing regimens, to determine whether the protease genotype influenced the outcome of the salvage regimen. Genotyping from 29 nelfinavir failures revealed D30N in 17 (59%) and L90M in 11 (38%) cases. Suppression to <400 viral RNA copies/mL was achieved at week 48 in 56% of patients with the D30N virus versus 18% of patients with the L90M virus