Details

Autor(en) / Beteiligte

• KAWANO, S.-I
• FUJIYAMA, S
• SATO, S
• TANAKA, M
• GOTO, M
• TAURA, Y
• SATO, T
• KAWAHARA, T
• MIZUNO, K
• NONAKA, S

Titel

Clinical evaluation of three anti-HCV ELISAs in patients with various liver diseases

Ist Teil von

• Digestive diseases and sciences, 1992-08, Vol.37 (8), p.1268-1274

Ort / Verlag

Heidelberg: Springer

Erscheinungsjahr

1992

Quelle

SpringerLINK Contemporary (Konsortium Baden-Württemberg)

Beschreibungen/Notizen

• We measured antibodies to hepatitis C virus (HCV) in 380 patients with various liver diseases by three enzyme-linked immunosorbent assays (ELISAs): HCV antibody ELISA test (C100), KCL-163 (KCL) corresponding to the nonstructural protein of HCV, and JCC based on the translation product of the presumptive HCV core gene. Of 233 cases of non-A, non-B (NANB) liver disease, 63.9% were anti-C100 positive, 69.1% were anti-KCL positive, and 79.8% were anti-JCC positive. Detection of serum HCV-RNA in 213 cases of chronic NANB liver disease revealed that the concordance was 80.3% for C100, 86.4% for KCL, 94.8% for JCC, and 95.3% for all three ELISAs. Overall, 85.4% of chronic NANB cases were considered to have type C disease with HCV infection. The most reliable assays for diagnosing chronic NANB liver disease as type C appeared to be the KCL and JCC ELISAs.