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Identification of the major histocompatibility complex in the ring-necked pheasant, Phasianus colchicus
Ist Teil von
Animal genetics, 1992-01, Vol.23 (3), p.211-220
Ort / Verlag
Oxford, UK: Blackwell Publishing Ltd
Erscheinungsjahr
1992
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Reciprocal immunization between parents of an Illinois family of ring‐necked pheasants, Phasianus colchicus, resulted in antisera detecting two pairs of alloantigens segregating among 13 progeny. The four alloantigens were tentatively designated as 1 and 2, transmitted antithetically by the sire, and 3 and 4, transmitted antithetically by the dam. Genetic segregation occurring in second‐generation progeny demonstrated that these two pairs of antigens belonged to a single genetic system. This alloantigen system was shown to correspond serologically to the major histocompatibility complex (MHC) of the chicken by cross‐reactivity of the antigens of this system with specific subregional chicken MHC reagents, appropriately absorbed with erythrocytes of individual pheasants. These four haplotypes of the pheasant MHC were subsequently designated as MhcPhco‐B1, MhcPhco‐B2, MhcPhco‐B3and MhcPhco‐B4. Traditional immunogenetic analysis of 30 pheasant families produced in this study disclosed a minimum of 14 pheasant haplotypes of this alloantigen system (MHC) to be segregating in the population under evaluation.