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Wnt3a Plays a Major Role in the Segmentation Clock Controlling Somitogenesis
Ist Teil von
Developmental cell, 2003-03, Vol.4 (3), p.395-406
Ort / Verlag
United States: Elsevier Inc
Erscheinungsjahr
2003
Quelle
MEDLINE
Beschreibungen/Notizen
The vertebral column derives from somites generated by segmentation of presomitic mesoderm (PSM). Somitogenesis involves a molecular oscillator, the segmentation clock, controlling periodic Notch signaling in the PSM. Here, we establish a novel link between Wnt/β-catenin signaling and the segmentation clock.
Axin2, a negative regulator of the Wnt pathway, is directly controlled by Wnt/β-catenin and shows oscillating expression in the PSM, even when Notch signaling is impaired, alternating with
Lfng expression. Moreover,
Wnt3a is required for oscillating Notch signaling activity in the PSM. We propose that the segmentation clock is established by Wnt/β-catenin signaling via a negative-feedback mechanism and that
Wnt3a controls the segmentation process in vertebrates.