Cancer genetics and cytogenetics, 1992-07, Vol.61 (2), p.204-206
1992
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Details
- Autor(en) / Beteiligte
- Titel
- Significant telomere shortening in childhood leukemia
- Ist Teil von
- Cancer genetics and cytogenetics, 1992-07, Vol.61 (2), p.204-206
- Ort / Verlag
- New York, NY: Elsevier Inc
- Erscheinungsjahr
- 1992
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- Telomere length was studied by Southern analysis in five cases of childhood acute leukemia. In four cases, the length of the telomere sequence of the blast phase cells was shortened as compared with that of the cells examined during remission. Study of telomere length during chemotherapy for hematologic malignancies may show rapidly dividing subpopulations of malignant cells and thereby guide further treatment needs. In addition, such loss of telomere sequence would give rise to chromosomal instability and could be one of the mechanisms of oncogene activation in acute leukemia.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0165-4608eISSN: 1873-4456DOI: 10.1016/0165-4608(92)90088-PTitel-ID: cdi_proquest_miscellaneous_73097996
- Format
- –
- Schlagworte
- Biological and medical sciences, Blotting, Southern, Child, Child, Preschool, Hematologic and hematopoietic diseases, Humans, Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics, Leukemia, Myeloid, Acute - genetics, Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis, Medical sciences, Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics, Repetitive Sequences, Nucleic Acid - genetics, Telomere - pathology