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Significant telomere shortening in childhood leukemia
Ist Teil von
Cancer genetics and cytogenetics, 1992-07, Vol.61 (2), p.204-206
Ort / Verlag
New York, NY: Elsevier Inc
Erscheinungsjahr
1992
Quelle
Access via ScienceDirect (Elsevier)
Beschreibungen/Notizen
Telomere length was studied by Southern analysis in five cases of childhood acute leukemia. In four cases, the length of the telomere sequence of the blast phase cells was shortened as compared with that of the cells examined during remission. Study of telomere length during chemotherapy for hematologic malignancies may show rapidly dividing subpopulations of malignant cells and thereby guide further treatment needs. In addition, such loss of telomere sequence would give rise to chromosomal instability and could be one of the mechanisms of oncogene activation in acute leukemia.