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Safety and use of sputum induction in children with cystic fibrosis
Pediatric pulmonology, 2003-04, Vol.35 (4), p.309-313
Suri, Ranjan
Marshall, Lindsay J.
Wallis, Colin
Metcalfe, Christopher
Shute, Janis K.
Bush, Andrew
2003
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Suri, Ranjan
Marshall, Lindsay J.
Wallis, Colin
Metcalfe, Christopher
Shute, Janis K.
Bush, Andrew
Titel
Safety and use of sputum induction in children with cystic fibrosis
Ist Teil von
Pediatric pulmonology, 2003-04, Vol.35 (4), p.309-313
Ort / Verlag
New York: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2003
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
We assessed the safety and use of induced sputum (IS) in children with cystic fibrosis (CF). Forty‐eight children (19 males) with CF, mean age 12.6 (range, 7.3–17.0) years and median forced expired volume in 1 sec (FEV1) 48% (range, 14–77%) predicted were recruited. Patients spontaneously expectorated sputum and then performed sputum induction by inhalation of nebulized 7% hypertonic saline. Samples were sent for bacteriological culture, and for measurement of the following inflammatory mediators: interleukin‐8, myeloperoxidase, eosinophil cationic protein, and neutrophil elastase activity. FEV1 was performed before and after inhalation of hypertonic saline. There was no increase in mediator levels in IS compared to expectorated sputum (ES) samples. Only 3 patients demonstrated significant bronchoconstriction following inhalation of hypertonic saline, by the method used. From the ES samples, Pseudomonas aeruginosa was isolated in 13 patients, Staphylococcus aureus in 7 patients, Stenotrophomonas maltophilia in 1 patient, and both Pseudomonas aeruginosa and Staphylococcus aureus in 5 patients. All these organisms were found in the IS samples. However, in 2 patients whose ES grew no organisms, one patient's IS grew Pseudomonas aeruginosa, and the other patient's IS grew Staphylococcus aureus. In our study, sputum induction was safe, with no proinflammatory effect. Pediatr Pulmonol. 2003; 35:309–313. © 2003 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 8755-6863
eISSN: 1099-0496
DOI: 10.1002/ppul.10226
Titel-ID: cdi_proquest_miscellaneous_73079768
Format
–
Schlagworte
Adolescent
,
Biological and medical sciences
,
Child
,
cystic fibrosis
,
Cystic Fibrosis - microbiology
,
Cystic Fibrosis - physiopathology
,
Female
,
Forced Expiratory Volume - drug effects
,
Humans
,
inflammation
,
Inflammation Mediators - analysis
,
Male
,
Medical sciences
,
Pneumology
,
Respiratory system : syndromes and miscellaneous diseases
,
Saline Solution, Hypertonic - pharmacology
,
Sputum - chemistry
,
Sputum - microbiology
,
sputum induction
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