Details

Autor(en) / Beteiligte

• Sabino, Mary Ann C.
• Luger, Nancy M.
• Mach, David B.
• Rogers, Scott D.
• Schwei, Matthew J.
• Mantyh, Patrick W.

Titel

Different tumors in bone each give rise to a distinct pattern of skeletal destruction, bone cancer‐related pain behaviors and neurochemical changes in the central nervous system

Ist Teil von

• International journal of cancer, 2003-05, Vol.104 (5), p.550-558

Ort / Verlag

New York: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

2003

Quelle

MEDLINE

Beschreibungen/Notizen

• Pain is the most common presenting symptom in patients with bone cancer and bone cancer pain can be both debilitating and difficult to control fully. To begin to understand the mechanisms involved in the generation and maintenance of bone cancer pain, we implanted 3 well‐described murine tumor cell lines, 2472 sarcoma, B16 melanoma and C26 colon adenocarcinoma into the femur of immunocompromised C3H‐SCID mice. Although each of the tumor cell lines proliferated and completely filled the intramedullary space of the femur within 3 weeks, the location and extent of bone destruction, the type and severity of the pain behaviors and the neurochemical reorganization of the spinal cord was unique to each tumor cell line injected. These data suggest that bone cancer pain is not caused by a single factor such as increased pressure induced by intramedullary tumor growth, but rather that multiple factors are involved in generating and maintaining bone cancer pain. © 2003 Wiley‐Liss, Inc.