Details

Autor(en) / Beteiligte

• Stadelmaier, Andreas
• Morath, Siegfried
• Hartung, Thomas
• Schmidt, Richard R.

Titel

Synthesis of the First Fully Active Lipoteichoic Acid

Ist Teil von

• Angewandte Chemie (International ed.), 2003-02, Vol.42 (8), p.916-920

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

2003

Quelle

MEDLINE

Beschreibungen/Notizen

• Nature outfoxed! Owing to the sensitivity of lipoteichoic acids (LTAs) to hydrolysis their biological activity could not be ascertained thus far. The chemical synthesis of LTA of Staphylococcus aureus 1, which contains hydrolytically labile D‐alanine residues in the required ratio with other substituents, resulted in the same activity as exhibited by the natural product obtained by a new isolation procedure. Thus, the biological activity of LTA could be ascertained for the first time.