Details

Autor(en) / Beteiligte

• Hill, Jonathan M
• Zalos, Gloria
• Halcox, Julian P.J
• Schenke, William H
• Waclawiw, Myron A
• Quyyumi, Arshed A
• Finkel, Toren

Titel

Circulating Endothelial Progenitor Cells, Vascular Function, and Cardiovascular Risk

Ist Teil von

• The New England journal of medicine, 2003-02, Vol.348 (7), p.593-600

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

2003

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• Endothelial progenitor cells are mononuclear cells of bone marrow origin that enter the circulation and may help maintain the vascular endothelium. This study found an inverse correlation between the number of circulating progenitor cells and cardiovascular risk and a direct correlation with endothelial function in the brachial artery. Studies have identified a cell population termed endothelial progenitor cells that can be isolated from circulating mononuclear cells, 1 – 3 bone marrow, 4 and cord blood. 5 Laboratory evidence suggests that these cells express a number of endothelial-specific cell-surface markers and exhibit numerous endothelial properties. 1 , 3 In addition, when these cells are injected into animal models with ischemia, they are rapidly incorporated into sites of neovascularization. 1 , 5 – 11 Ross's classic paradigm states that endothelial-cell injury is the stimulus for the development of atherosclerotic plaque. 12 This model argues that seemingly disparate risk factors act on a final common pathway that culminates in endothelial-cell injury. . . .