Life Sciences, 1992, Vol.51 (2), p.83-94
1992
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Endocrine and receptor pharmacology of serotonergic anxiolytics, antipsychotics and antidepressants
- Ist Teil von
- Life Sciences, 1992, Vol.51 (2), p.83-94
- Ort / Verlag
- Amsterdam: Elsevier Inc
- Erscheinungsjahr
- 1992
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- Several classes of drugs that modify serotonin (5-HT) neurotransmission are either currently used, or are being evaluated for their potential use in the treatment of anxiety, schizophrenia, and depression. 5-HT 1A agonists are considered potential anxiolytics, while some atypical antipsychotics are potent 5-HT 2 antagonists (and also have modest dopamine D 2 affinity). Furthermore, there is a diverse group of serotonergic drugs that may be effective antidepressants. Secretion of ACTH, corticosterone/cortisol, prolactin, renin, oxytocin and vasopressin are stimulated by activation of different 5-HT receptor subtypes, while other neurotransmitter receptors also influence the secretion of these hormones. We compared the receptor binding profiles of 5-HT anxiolytics, antipsychotics and antidepressants with their endocrine effects. These comparisons could aid in understanding both the therapeutic and side effects of these drugs.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0024-3205eISSN: 1879-0631DOI: 10.1016/0024-3205(92)90001-6Titel-ID: cdi_proquest_miscellaneous_73021416
- Format
- –
- Schlagworte
- Anti-Anxiety Agents - metabolism, Anti-Anxiety Agents - pharmacology, Antidepressive Agents - metabolism, Antidepressive Agents - pharmacology, Antipsychotic Agents - metabolism, Antipsychotic Agents - pharmacology, Biological and medical sciences, Endocrine Glands - drug effects, Endocrine Glands - metabolism, Humans, Medical sciences, Neuropharmacology, Pharmacology. Drug treatments, Psycholeptics: tranquillizer, neuroleptic, Psychology. Psychoanalysis. Psychiatry, Psychopharmacology, Receptors, Dopamine - drug effects, Receptors, Dopamine - metabolism, Receptors, Dopamine D2, Receptors, Serotonin - drug effects, Receptors, Serotonin - metabolism, Serotonin - metabolism, Serotonin Antagonists - metabolism, Serotonin Antagonists - pharmacology