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Biochemical and molecular pharmacology of kinin receptors
Ist Teil von
Annual review of pharmacology and toxicology, 1992-01, Vol.32 (1), p.511-536
Ort / Verlag
United States
Erscheinungsjahr
1992
Quelle
MEDLINE
Beschreibungen/Notizen
Bradykinin (BK; Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg) is a potent inflammatory peptide whose generation in tissues and body fluids elicits numerous responses including vasodilation, edema, smooth muscle spasm, as well as pain and hyperalgesia via stimulation of C- and A-fibers. There is substantial evidence that BK and related kinins, such as kallidin (Lys-BK, or KD), contribute to the inflammatory response in acute and chronic diseases including allergic reactions, arthritis, asthma, sepsis, viral rhinitis, and inflammatory bowel diseases. The past few years have witnessed an abundance of reviews on regulation of the biosynthesis, release, and degradation of kinins, in addition to their physiological and pathophysiological effects. Here we highlight recent advances in our understanding of biochemical and molecular aspects of kinin receptor pharmacology. (DBO)