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Human papillomavirus infection as a prognostic factor in carcinomas of the oral cavity and oropharynx
International journal of cancer, 2003-04, Vol.104 (3), p.336-344
Ritchie, Justine M.
Smith, Elaine M.
Summersgill, Kurt F.
Hoffman, Henry T.
Wang, Donghong
Klussmann, Jens P.
Turek, Lubomir P.
Haugen, Thomas H.
2003
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Ritchie, Justine M.
Smith, Elaine M.
Summersgill, Kurt F.
Hoffman, Henry T.
Wang, Donghong
Klussmann, Jens P.
Turek, Lubomir P.
Haugen, Thomas H.
Titel
Human papillomavirus infection as a prognostic factor in carcinomas of the oral cavity and oropharynx
Ist Teil von
International journal of cancer, 2003-04, Vol.104 (3), p.336-344
Ort / Verlag
New York: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2003
Quelle
Wiley Online Library All Journals
Beschreibungen/Notizen
Although studies have established human papillomaviruses (HPVs) as a risk factor for oral and oropharyngeal cancer, it is not clear whether viral infection affects survival in head and neck malignancies. This investigation examined the relationship between HPV and survival in carcinomas of the oral cavity and oropharynx. Formalin‐fixed, paraffin‐embedded tumor specimens from 139 newly diagnosed cases were tested for HPVs by PCR and DNA sequencing. Patient and tumor characteristics were obtained from questionnaires, pathology reports and cancer registries. Odds ratios (ORs) and relative risks (RRs) were based on logistic and Cox regression models, respectively. HPVs were detected in 21% of the tumors; 83% were HPV‐16. Greater risk of HPV infection was associated with males (OR = 2.9, 95% CI = 1.0–8.6), a history of oral‐genital sex (OR = 4.2, 95% CI = 1.5–11.7), and oropharyngeal tumors (OR = 10.4, 95% CI = 3.5–31.2). As tobacco usage increased, the odds of HPV detection decreased (OR = 0.97/pack‐year, 95% CI = 0.96–0.99). HPV infected patients had better overall survival (RR = 0.3, 95% CI = 0.1–0.8) than those with HPV‐negative tumors. There was an interaction between gender and HPV for overall (p = 0.05) and disease‐specific (p = 0.03) survival that suggested that HPV infected males had better prognosis than HPV‐negative males, but this was not the case among females. HPV status was identified as an independent prognostic factor in oral and oropharyngeal cancers. This result appeared to be gender‐specific, suggesting the need for further study of the interaction between HPV and gender on survival. © 2003 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0020-7136
eISSN: 1097-0215
DOI: 10.1002/ijc.10960
Titel-ID: cdi_proquest_miscellaneous_73007366
Format
–
Schlagworte
Adult
,
Aged
,
Aged, 80 and over
,
Biological and medical sciences
,
Carcinoma, Squamous Cell - mortality
,
Carcinoma, Squamous Cell - virology
,
Case-Control Studies
,
DNA, Viral - analysis
,
Female
,
human papillomavirus
,
Humans
,
Male
,
Medical sciences
,
Middle Aged
,
Mouth Neoplasms - mortality
,
Mouth Neoplasms - virology
,
Neoplasm Staging
,
Odds Ratio
,
oral cancer
,
oral cavity
,
Oropharyngeal Neoplasms - mortality
,
Oropharyngeal Neoplasms - virology
,
oropharynx
,
Otorhinolaryngology. Stomatology
,
Papillomaviridae - genetics
,
Papillomaviridae - isolation & purification
,
Papillomavirus Infections - mortality
,
Papillomavirus Infections - virology
,
Prevalence
,
Prognosis
,
Risk Factors
,
survival
,
Survival Rate
,
Tumor Virus Infections - mortality
,
Tumor Virus Infections - virology
,
Tumors
,
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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