Details

Autor(en) / Beteiligte

• Frindel, E
• Masse, A
• Pradelles, P
• Volkov, L
• Rigaud, M

Titel

Correlation of endogenous acetyl-ser-asp-lys-pro plasma levels in mice and the kinetics of pluripotent hemopoietic stem cells entry into the cycle after cytosine arabinoside treatment: fundamental and clinical aspects

Ist Teil von

• Leukemia, 1992-06, Vol.6 (6), p.599

Ort / Verlag

England

Erscheinungsjahr

1992

Quelle

MEDLINE

Beschreibungen/Notizen

• A decrease of endogenous acetyl-ser-asp-lys-pro (AcSDKP) levels in murine plasma was observed after Ara-C treatment. This decrease preceded the entry of pluripotent hemopoietic stem cells (CFU-S) into the cell cycle. This suggests a correlation between CFU-S kinetics and levels of endogenous AcSDKP. The subsequent increase of AcSDKP levels seem to indicate a feedback mechanism which should permit the reestablishment of homeostasis in the stem cells. Therefore, the expulsion of the physiological brake may be the response to a signal (stimulatory factors) to start dividing and the retention of the physiological brake may the mechanism for a return to normal values of cell proliferation.