Details

Autor(en) / Beteiligte

• TODD, R. D
• LOBOS, E. A
• SUN, L-W
• NEUMAN, R. J

Titel

Mutational analysis of the nicotinic acetylcholine receptor alpha 4 subunit gene in attention deficit hyperactivity disorder: evidence for association of an intronic polymorphism with attention problems

Ist Teil von

• Molecular psychiatry, 2003, Vol.8 (1), p.103-108

Ort / Verlag

Basingstoke: Nature Publishing Group

Erscheinungsjahr

2003

Quelle

EBSCOhost Psychology and Behavioral Sciences Collection

Beschreibungen/Notizen

• Recent studies suggest the presence of genetically distinct subtypes of attention deficit/hyperactivity disorder (ADHD) and that attention problems can be treated with receptor subtype selective nicotine agonists. In this study, individuals with two independent familial subtypes of ADHD defined by latent class analysis were systematically screened for sequence variations in the coding regions and intron/exon junctions of the nicotinic acetylcholine receptor alpha 4 subunit gene (CHRNA4). Common polymorphisms were used for transmission disequilibrium test (TDT) analyses. A significant association was found for a 5' intron 2 single nucleotide polymorphism and severe inattention problems (P = 0.007, effect size = 4, 95% CI 1.3-14.1). The location of the polymorphism is compatible with it affecting pre-mRNA stability or splicing.