Details

Autor(en) / Beteiligte

• Brown, Robin M.
• Cruz, Orlando
• Brennan, Michael
• Gennaro, Maria L.
• Schlesinger, Larry
• Skeiky, Yasir A. W.
• Hoft, Daniel F.

Titel

Lipoarabinomannan-Reactive Human Secretory Immunoglobulin A Responses Induced by Mucosal Bacille Calmette-Guérin Vaccination

Ist Teil von

• The Journal of infectious diseases, 2003-02, Vol.187 (3), p.513-517

Ort / Verlag

Chicago, IL: The University of Chicago Press

Erscheinungsjahr

2003

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• The ability of 17 recombinant mycobacterial proteins, native antigen 85 complex, lipoarabinomannan (LAM), and Mycobacterium tuberculosis lysate to detect antibody responses induced by bacille Calmette-Guérin (BCG) vaccination and active tuberculosis infection were studied in enzyme-linked immunosorbent assays. Only LAM-reactive serum immunoglobulin G responses were significantly increased in both BCG-vaccinated patients and patients with active tuberculosis (P<.05), and oral BCG vaccination also induced significant increases in LAM-reactive secretory immunoglobulin A (P<.05). LAM-reactive antibody assays can serve as markers of humoral and mucosal immunity in future trials of BCG and newer attenuated mycobacterial vaccines