UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 17 von 20
Datensatz exportieren als...
BibTeX
Friedrich Sigmund Merkel and his “Merkel cell”, morphology, development, and physiology: Review and new results
The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology, 2003-03, Vol.271A (1), p.225-239
Halata, Zdenek
Grim, Milos
Bauman, Klaus I.
2003
Details
Autor(en) / Beteiligte
Halata, Zdenek
Grim, Milos
Bauman, Klaus I.
Titel
Friedrich Sigmund Merkel and his “Merkel cell”, morphology, development, and physiology: Review and new results
Ist Teil von
The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology, 2003-03, Vol.271A (1), p.225-239
Ort / Verlag
New York: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2003
Link zum Volltext
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
Merkel nerve endings are mechanoreceptors in the mammalian skin. They consist of large, pale cells with lobulated nuclei forming synapse‐like contacts with enlarged terminal endings of myelinated nerve fibers. They were first described by F.S. Merkel in 1875. They are found in the skin and in those parts of the mucosa derived from the ectoderm. In mammals (apart from man), the largest accumulation of Merkel nerve endings is found in whiskers. In all vertebrates, Merkel nerve endings are located in the basal layer of the epidermis, apart from birds, where they are located in the dermis. Cytoskeletal filaments consisting of cytokeratins and osmiophilic granules containing a variety of neuropeptides are found in Merkel cells. In anseriform birds, groups of cells resembling Merkel cells, with discoid nerve terminals between cells, form Grandry corpuscles. There has been controversy over the origin of Merkel cells. Results from chick/quail chimeras show that, in birds, Merkel cells are a subpopulation of cells derived from the neural crest, which thus excludes their development from the epidermis. Most recently, also in mammals, conclusive evidence for a neural crest origin of Merkel cells has been obtained. Merkel cells and nerve terminals form mechanoreceptors. Calcium ions enter Merkel cells in response to mechanical stimuli, a process which triggers the release of calcium from intracellular stores resulting in exocytosis of neurotransmitter or neuromodulator. Recent results suggest that there may be glutamatergic transmission between Merkel cell and nerve terminal, which appears to be essential for the characteristic slowly adapting response of these receptors during maintained mechanical stimuli. Thus, we are convinced that Merkel cells with associated nerve terminals function as mechanoreceptor cells. Cells in the skin with a similar appearance as Merkel cells, but without contact to nerve terminals, are probably part of a diffuse neuroendocrine system and do not function as mechanoreceptors. Probably these cells, rather than those acting as mechanoreceptors, are the origin of a highly malignant skin cancer called Merkel cell carcinoma. Anat Rec Part A 271A:225–239, 2003. © 2003 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1552-4884
eISSN: 1552-4892
DOI: 10.1002/ar.a.10029
Titel-ID: cdi_proquest_miscellaneous_72987029
Format
–
Schlagworte
Animals
,
Epidermis - cytology
,
Epidermis - embryology
,
Epidermis - ultrastructure
,
Humans
,
mechanoreceptor
,
Mechanoreceptors - ultrastructure
,
Merkel cell
,
Merkel Cells - cytology
,
Merkel Cells - physiology
,
Merkel Cells - ultrastructure
,
Merkel nerve ending
,
Nerve Endings - ultrastructure
,
Neural Crest - embryology
,
neuroendocrine cell
,
Skin - cytology
,
Skin - innervation
,
Skin - ultrastructure
,
Tastscheibe
,
touch dome
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX