Details

Autor(en) / Beteiligte

• Yáñez-Mó, María
• Lara-Pezzi, Enrique
• Selgas, Rafael
• Ramírez-Huesca, Marta
• Domínguez-Jiménez, Carmen
• Jiménez-Heffernan, José A
• Aguilera, Abelardo
• Sánchez-Tomero, José A
• Bajo, M. Auxiliadora
• Álvarez, Vincente
• Castro, M. Angeles
• del Peso, Gloria
• Cirujeda, Antonio
• Gamallo, Carlos
• Sánchez-Madrid, Francisco
• López-Cabrera, Manuel

Titel

Peritoneal Dialysis and Epithelial-to-Mesenchymal Transition of Mesothelial Cells

Ist Teil von

• The New England journal of medicine, 2003-01, Vol.348 (5), p.403-413

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

2003

Quelle

MEDLINE

Beschreibungen/Notizen

• In continuous ambulatory peritoneal dialysis, bioincompatible fluids bathe the peritoneum, causing denudation of the mesothelial cells and, eventually, tissue fibrosis. This study characterized mesothelial cells from effluents in dialysis fluid. Soon after dialysis is initiated, peritoneal mesothelial cells undergo a transition from an epithelial phenotype to a mesenchymal phenotype, with progressive loss of epithelial morphology and changes in gene expression characteristic of a profibrotic state. Continuous ambulatory peritoneal dialysis is an alternative to hemodialysis for the treatment of end-stage renal disease. 1 The peritoneal membrane is lined with a monolayer of mesothelial cells that have some characteristics of epithelial cells, act as a permeability barrier, and secrete various substances involved in the regulation of peritoneal permeability and local host defense. 1 , 2 Unfortunately, long-term exposure to the hyperosmotic, hyperglycemic, and acidic solutions used in dialysis often causes low-grade, chronic inflammation of and injury to the peritoneum, which progressively becomes denuded of mesothelial cells and undergoes fibrosis. 1 Such structural alterations are considered to be the principal cause of . . .