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Expression of chemokines and their receptors in human and simian astrocytes: Evidence for a central role of TNFα and IFNγ in CXCR4 and CCR5 modulation
Glia, 2003-03, Vol.41 (4), p.354-370
Croitoru-Lamoury, Juliana
Guillemin, Gilles J.
Boussin, François D.
Mognetti, Barbara
Gigout, Laure I.
Chéret, Arnaud
Vaslin, Bruno
Le Grand, Roger
Brew, Bruce J.
Dormont, Dominique
2003
Details
Autor(en) / Beteiligte
Croitoru-Lamoury, Juliana
Guillemin, Gilles J.
Boussin, François D.
Mognetti, Barbara
Gigout, Laure I.
Chéret, Arnaud
Vaslin, Bruno
Le Grand, Roger
Brew, Bruce J.
Dormont, Dominique
Titel
Expression of chemokines and their receptors in human and simian astrocytes: Evidence for a central role of TNFα and IFNγ in CXCR4 and CCR5 modulation
Ist Teil von
Glia, 2003-03, Vol.41 (4), p.354-370
Ort / Verlag
New York: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2003
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Chemokines are key mediators of the selective migration of leukocytes that occurs in neurodegenerative diseases and related inflammatory processes. Astrocytes, the most abundant cell type in the CNS, have an active role in brain inflammation. To ascertain the role of astrocytes during neuropathological processes, we have investigated in two models of primary cells (human fetal and simian adult astrocytes) the repertoire of chemokines and their receptors expressed in response to inflammatory stimuli. We demonstrated that, in the absence of any stimulation, human fetal and simian adult astrocytes express mRNA for receptors APJ, BOB/GPR15, Bonzo/CXCR6, CCR2, CCR3, CCR5, CCR8, ChemR23, CXCR3/GPR9, CXCR4, GPR1, and V28/CX3CR1. Moreover, TNFα and IL‐1β significantly increase BOB/GPR15, CCR2, and V28/CX3CR1 mRNA levels in both models. Furthermore, TNFα and IFNγ act synergistically to induce expression of the major coreceptors for HIV infection, CXCR4 and CCR5, at both the mRNA and protein levels in human and simian astrocytes, whereas CCR3 expression was not affected by cytokine treatment. Finally, TNFα/IFNγ was the most significant cytokine combination in leading to a pronounced upregulation in a comparable, time‐dependent manner of the production of chemokines IP‐10/CXCL10, RANTES/CCL5, MIG/CXCL9, MCP‐1/CCL2, and IL‐8/CXCL8. In summary, these data suggest that astrocytes serve as an important source of chemokines under the dependence of a complex cytokine regulation, and TNFα and IFNγ are important modulators of chemokines and chemokine receptor expression in human as well as simian astrocytes. Finally, with the conditions we used, there was no difference between species or age of tissue. GLIA 41:354–370, 2003. © 2003 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0894-1491
eISSN: 1098-1136
DOI: 10.1002/glia.10181
Titel-ID: cdi_proquest_miscellaneous_72980771
Format
–
Schlagworte
Animals
,
astrocyte
,
Astrocytes - cytology
,
Astrocytes - drug effects
,
Astrocytes - metabolism
,
Biological and medical sciences
,
Cells, Cultured
,
chemokine
,
Chemokines - biosynthesis
,
Chemokines - pharmacology
,
CNS
,
Fetus
,
Fundamental and applied biological sciences. Psychology
,
human
,
Humans
,
Interferon-gamma - biosynthesis
,
Interferon-gamma - pharmacology
,
Isolated neuron and nerve. Neuroglia
,
Macaca fascicularis
,
Macaca mulatta
,
receptor
,
Receptors, CCR5 - biosynthesis
,
Receptors, Chemokine - biosynthesis
,
Receptors, CXCR4 - biosynthesis
,
RNA, Messenger - biosynthesis
,
simian
,
Tumor Necrosis Factor-alpha - biosynthesis
,
Tumor Necrosis Factor-alpha - pharmacology
,
Vertebrates: nervous system and sense organs
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