Bioorganic & medicinal chemistry, 2003-02, Vol.11 (4), p.515-520
2003
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Details
- Autor(en) / Beteiligte
- Titel
- Importance of the thiomorpholine introduction in new pyrrole derivatives as antimycobacterial agents analogues of BM 212
- Ist Teil von
- Bioorganic & medicinal chemistry, 2003-02, Vol.11 (4), p.515-520
- Ort / Verlag
- Oxford: Elsevier Ltd
- Erscheinungsjahr
- 2003
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- During the course of our investigations in the field of azole antimicrobial agents, we have identified BM 212, a pyrrole derivative with good in vitro activity against mycobacteria and candidae. These findings prompted us to prepare new pyrrole derivatives 1– 10 in the hope of increasing the activity. The microbiological data showed interesting in vitro activity against Mycobacterium tuberculosis and atypical mycobacteria. Previously we have identified BM 212, a pyrrole derivative with good in vitro activity against mycobacteria and candidae. These findings prompted us to prepare new pyrrole derivatives in the hope of increasing the activity. The microbiological data showed interesting in vitro activity against Mycobacterium tuberculosis and atypical mycobacteria.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0968-0896eISSN: 1464-3391DOI: 10.1016/S0968-0896(02)00455-8Titel-ID: cdi_proquest_miscellaneous_72978960
- Format
- –
- Schlagworte
- Anti-Bacterial Agents - chemical synthesis, Anti-Bacterial Agents - pharmacology, Antibacterial agents, Antibiotics, Antitubercular, Antibiotics. Antiinfectious agents. Antiparasitic agents, Antifungal Agents - chemical synthesis, Antifungal Agents - pharmacology, Antitubercular Agents - pharmacology, Antiviral Agents - chemical synthesis, Antiviral Agents - pharmacology, Binding Sites, Biological and medical sciences, Chemical Phenomena, Chemistry, Physical, Indicators and Reagents, Isoniazid - pharmacology, Medical sciences, Microbial Sensitivity Tests, Models, Molecular, Molecular Conformation, Morpholines - chemical synthesis, Morpholines - pharmacology, Mycobacterium - drug effects, Pharmacology. Drug treatments, Piperazines - chemistry, Piperazines - pharmacology, Pyrroles - chemical synthesis, Pyrroles - chemistry, Pyrroles - pharmacology, Rifampin - pharmacology, Streptomycin - pharmacology, Structure-Activity Relationship