Details

Autor(en) / Beteiligte

• Hannon, Robert
• Croxtall, Jamie D.
• Getting, Stephen J.
• Roviezzo, Fiorentina
• Yona, Simon
• Paul‐Clark, Mark J.
• Gavins, Felicity N. E.
• Perretti, Mauro
• Morris, John F.
• Buckingham, Julia C.
• Flower, Roderick J.

Titel

Aberrant inflammation and resistance to glucocorticoids in Annexin 1−/− Mouse

Ist Teil von

• The FASEB journal, 2003-02, Vol.17 (2), p.253-255

Ort / Verlag

United States: Federation of American Societies for Experimental Biology

Erscheinungsjahr

2003

Link zum Volltext

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• The 37‐kDa protein annexin 1 (Anx‐1; lipocortin 1) has been implicated in the regulation of phagocytosis, cell signaling, and proliferation and is postulated to be a mediator of glucocorticoid action in inflammation and in the control of anterior pituitary hormone release. Here, we report that mice lacking the Anx‐1 gene exhibit a complex phenotype that includes an altered expression of other annexins as well as of COX‐2 and cPLA2. In carrageenin‐ or zymosan‐induced inflammation, Anx‐1−/− mice exhibit an exaggerated response to the stimuli characterized by an increase in leukocyte emigration and IL‐1β generation and a partial or complete resistance to the antiinflammatory effects of glucocorticoids. Anx‐1−/− polymorphonuclear leucocytes exhibited increased spontaneous migratory behavior in vivo whereas in vitro, leukocytes from Anx‐1−/− mice had reduced cell surface CD 11b (MAC‐1) but enhanced CD62L (L‐selectin) expression and Anx‐1−/− macrophages exhibited anomalies in phagocytosis. There are also gender differences in activated leukocyte behavior in the Anx‐1−/−mice that are not seen in the wild‐type animals, suggesting an interaction between sex hormones and inflammation in Anx‐1−/− animals.