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Adiponectin and protection against type 2 diabetes mellitus
Ist Teil von
The Lancet (British edition), 2003-01, Vol.361 (9353), p.226-228
Ort / Verlag
London: Elsevier Ltd
Erscheinungsjahr
2003
Link zum Volltext
Quelle
EBSCOhost Business Source Ultimate
Beschreibungen/Notizen
Adiponectin is an adipocyte-derived peptide, which has antiinflammatory and insulin-sensitising properties. We designed a nested case-control study to assess whether baseline adiponectin concentrations in plasma are independently associated with risk of type 2 diabetes. We found that adiponectin concentrations in plasma were lower among individuals who later developed type 2 diabetes than among controls (mean 5·34 μg/mL [SD 3·49] vs 6·87 μg/mL [4·58], p<0·0001). High concentrations of adiponectin were associated with a substantially reduced relative risk of type 2 diabetes after adjustment for age, sex, waist-to-hip ratio, body-mass index, smoking, exercise, alcohol consumption, education, and glycosylated haemoglobin A1c (odds ratio 4th vs 1st quartile 0·3 [95% CI 0·2–0·7], p=0·0051). We conclude that adiponectin is independently associated with a reduced risk of type 2 diabetes in apparently healthy individuals.