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Frequency of gastrointestinal involvement and its clinical significance in mantle cell lymphoma
Cancer, 2003-02, Vol.97 (3), p.586-591
Romaguera, Jorge E.
Medeiros, L. Jeffrey
Hagemeister, Frederick B.
Fayad, Luis E.
Rodriguez, Maria A.
Pro, Barbara
Younes, Anas
McLaughlin, Peter
Goy, Andre
Sarris, Andreas H.
Dang, Nan H.
Samaniego, Felipe
Brown, H. M.
Gagneja, Harish K.
Cabanillas, Fernando
2003
Volltextzugriff (PDF)
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Autor(en) / Beteiligte
Romaguera, Jorge E.
Medeiros, L. Jeffrey
Hagemeister, Frederick B.
Fayad, Luis E.
Rodriguez, Maria A.
Pro, Barbara
Younes, Anas
McLaughlin, Peter
Goy, Andre
Sarris, Andreas H.
Dang, Nan H.
Samaniego, Felipe
Brown, H. M.
Gagneja, Harish K.
Cabanillas, Fernando
Titel
Frequency of gastrointestinal involvement and its clinical significance in mantle cell lymphoma
Ist Teil von
Cancer, 2003-02, Vol.97 (3), p.586-591
Ort / Verlag
New York: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2003
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
BACKGROUND The reported frequency of gastrointestinal (GI) tract involvement in patients with mantle cell lymphoma (MCL) is 15–30%. However, this figure most likely is an underestimate because most patients with MCL involving the GI tract previously reported were examined endoscopically only if they had GI tract symptoms. The impact of endoscopic assessment on the management of MCL patients is unknown. METHODS From March 1998 to May 2001 baseline upper and lower endoscopy of the GI tract was performed in consecutive untreated patients with MCL as part of a prospective therapeutic trial. Biopsies were performed on abnormal as well as macroscopically normal mucosa. Endoscopy was repeated during treatment and as part of follow‐up evaluations. RESULTS Only 26% of patients presented with GI symptoms at the time of diagnosis. MCL was present histologically in the lower GI tract of 53 of 60 patient (88%) and in the upper GI tract of 28 of 58 patients (43%). Microscopic evidence of MCL was found in 84% of patients with normal visual (macroscopic) findings by lower endoscopy and in 45% of patients with macroscopically normal findings by upper endoscopy. Despite this high frequency of GI tract involvement, the use of upper and lower endoscopy with biopsies in this group of patients resulted in changes in clinical management in only three (4%) patients. CONCLUSIONS Gastrointestinal tract involvement was found to be present in most patients with MCL, usually at a microscopic level involving macroscopically normal mucosa. The use of aggressive staging evaluation of the GI tract was found to have little impact on patient management decisions in the current study. Cancer 2003;97:586–91. © 2003 American Cancer Society. DOI 10.1002/cncr.11096 In a prospective endoscopic study, the authors found that patients with mantle cell lymphoma (MCL) have a high frequency of gastrointestinal tract involvement. The authors suggest that MCL homes to this anatomic site. Intensive endoscopic surveillance was found to have little impact on the management of MCL patients in the current study.
Sprache
Englisch
Identifikatoren
ISSN: 0008-543X
eISSN: 1097-0142
DOI: 10.1002/cncr.11096
Titel-ID: cdi_proquest_miscellaneous_72969935
Format
–
Schlagworte
Adult
,
Aged
,
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
,
Biological and medical sciences
,
Biopsy
,
endoscopy
,
Endoscopy, Digestive System
,
Gastrointestinal Neoplasms - diagnosis
,
gastrointestinal tract
,
Hematologic and hematopoietic diseases
,
Humans
,
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
,
Lymphoma, Mantle-Cell - diagnosis
,
Lymphoma, Mantle-Cell - drug therapy
,
Lymphoma, Mantle-Cell - physiopathology
,
mantle cell lymphoma
,
Medical sciences
,
Middle Aged
,
patient management
,
Prospective Studies
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