Details

Autor(en) / Beteiligte

• Stamm, Christof
• Westphal, Bernd
• Kleine, Hans-Dieter
• Petzsch, Michael
• Kittner, Christian
• Klinge, Heiko
• Schümichen, Carl
• Nienaber, Christoph A
• Freund, Mathias
• Steinhoff, Gustav

Titel

Autologous bone-marrow stem-cell transplantation for myocardial regeneration

Ist Teil von

• The Lancet (British edition), 2003-01, Vol.361 (9351), p.45-46

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2003

Quelle

EBSCOhost Business Source Ultimate

Beschreibungen/Notizen

• Implantation of bone-marrow stem cells in the heart might be a new method to restore tissue viability after myocardial infarction. We injected up to 1.5×10 6 autologous AC133+ bone-marrow cells into the infarct border zone in six patients who had had a myocardial infarction and undergone coronary artery bypass grafting. 3–9 months after surgery, all patients were alive and well, global left-ventricular function was enhanced in four patients, and infarct tissue perfusion had improved strikingly in five patients. We believe that implantation of AC133+ stem cells to the heart is safe and might induce angiogenesis, thus improving perfusion of the infarcted myocardium.