Details

Autor(en) / Beteiligte

• Renzi, Cristina
• Douglas, John M.
• Foster, Mark
• Critchlow, Cathy W.
• Ashley-Morrow, Rhoda
• Buchbinder, Susan P.
• Koblin, Beryl A.
• McKirnan, David J.
• Mayer, Kenneth H.
• Celum, Connie L.

Titel

Herpes Simplex Virus Type 2 Infection as a Risk Factor for Human Immunodeficiency Virus Acquisition in Men Who Have Sex with Men

Ist Teil von

• The Journal of infectious diseases, 2003-01, Vol.187 (1), p.19-25

Ort / Verlag

Chicago, IL: The University of Chicago Press

Erscheinungsjahr

2003

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• The association of human immunodeficiency virus (HIV) acquisition with herpes simplex virus type 2 (HSV-2) was assessed among men who have sex with men (MSM) in a nested case-control study of 116 case subjects who seroconverted to HIV during follow-up and 342 control subjects who remained HIV seronegative, frequency-matched by follow-up duration and report of HIV-infected sex partner and unprotected anal sex. The baseline HSV-2 seroprevalence was higher among case (46%) than control (34%) subjects (P=.03); the HSV-2 seroincidence was 7% versus 4% (P=.3). Only 15% of HSV-2–infected MSM reported herpes outbreaks in the past year. HIV acquisition was associated with prior HSV-2 infection (odds ratio [OR], 1.8; 95% confidence interval [CI], 1.1–2.9), reporting >12 sex partners (OR, 2.9; 95% CI, 1.4–6.3), and reporting fewer herpes outbreaks in the past year (OR, 0.3; 95% CI, 0.1–0.8). HSV-2 increases the risk of HIV acquisition, independent of recognized herpes lesions and behaviors reflecting potential HIV exposure. HSV-2 suppression with antiviral therapy should be evaluated as an HIV prevention strategy among MSM