Details

Autor(en) / Beteiligte

• Klucher, Kevin M
• Sheppard, Paul
• Kindsvogel, Wayne
• Xu, Wenfeng
• Henderson, Katherine
• Schlutsmeyer, Stacy
• Whitmore, Theodore E
• Kuestner, Rolf
• Garrigues, Ursula
• Birks, Carl
• Roraback, Jenny
• Ostrander, Craig
• Dong, Dennis
• Shin, Jinu
• Presnell, Scott
• Fox, Brian
• Haldeman, Betty
• Cooper, Emily
• Taft, David
• Gilbert, Teresa
• Grant, Francis J
• Tackett, Monica
• Krivan, William
• McKnight, Gary
• Clegg, Chris
• Foster, Don

Titel

IL-28, IL-29 and their class II cytokine receptor IL-28R

Ist Teil von

• Nature immunology, 2003-01, Vol.4 (1), p.63-68

Ort / Verlag

United States: Nature Publishing Group

Erscheinungsjahr

2003

Quelle

MEDLINE

Beschreibungen/Notizen

• Cytokines play a critical role in modulating the innate and adaptive immune systems. Here, we have identified from the human genomic sequence a family of three cytokines, designated interleukin 28A (IL-28A), IL-28B and IL-29, that are distantly related to type I interferons (IFNs) and the IL-10 family. We found that like type I IFNs, IL-28 and IL-29 were induced by viral infection and showed antiviral activity. However, IL-28 and IL-29 interacted with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor beta (IL-10Rbeta) and an orphan class II receptor chain, designated IL-28Ralpha. This newly described cytokine family may serve as an alternative to type I IFNs in providing immunity to viral infection.