Details

Autor(en) / Beteiligte

• Bax, Bridget E.
• Alam, A.S.M.Towhidul
• Banerji, Bashab
• Bax, Christopher M.R.
• Bevis, Peter J.R.
• Stevens, Clifford R.
• Moonga, Baljit S.
• Blake, David R.
• Zaidi, Mone

Titel

Stimulation of osteoclastic bone resorption by hydrogen peroxide

Ist Teil von

• Biochemical and biophysical research communications, 1992-03, Vol.183 (3), p.1153-1158

Ort / Verlag

San Diego, CA: Elsevier Inc

Erscheinungsjahr

1992

Link zum Volltext

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• The molecular mechanisms underlying the pathophysiology of bone destruction still remain poorly understood. We have found that hydrogen peroxide (H 2O 2), a reactive oxygen species (ROS), is a potent stimulator of osteoclastic bone resorption and cell motility. A marked enhancement of bone resorption was noted when rat osteoclasts, cultured on devitalised bovine cortical bone, were exposed to 10 nM [H 2O 2]. Apart from exposing osteoclasts to a low extracellular pH, which is known to enhance osteoclastic bone resorption, we provide first evidence for a molecule that stimulates osteoclastic bone resorption in osteoclast cultures that do not respond to parathyroid hormone and 1, 25 dihydroxyvitamin D 3. We envisage that both basic biological and practical clinical implications may eventually follow from these studies.