Details

Autor(en) / Beteiligte

• Hugger, Erin D.
• Cole, Clayton J.
• Raub, Thomas J.
• Burton, Philip S.
• Borchardt, Ronald T.

Titel

Automated Analysis of Polyethylene Glycol-Induced Inhibition of P-Glycoprotein Activity In Vitro

Ist Teil von

• Journal of pharmaceutical sciences, 2003-01, Vol.92 (1), p.21-26

Ort / Verlag

New York: Elsevier Inc

Erscheinungsjahr

2003

Link zum Volltext

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Previous studies in our laboratories have shown that commonly used polyethoxylated pharmaceutical excipients inhibit P-glycoprotein activity in cell culture models of the intestinal mucosa. The results presented in this technical note show that the TECAN Genesis™ robotic workstation can be utilized to automate cellular transport studies for evaluating excipient effects on P-glycoprotein activity in vitro and for estimating the permeation of drug-like molecules across cell monolayers.