Details

Autor(en) / Beteiligte

• Toomey, Deirdre
• Smyth, Gordon
• Condron, Claire
• Kelly, James
• Byrne, Ann‐Marie
• Kay, Elaine
• Conroy, Ronan M.
• Broe, Patrick
• Bouchier‐Hayes, David

Titel

Infiltrating immune cells, but not tumour cells, express FasL in non‐small cell lung cancer: No association with prognosis identified in 3‐year follow‐up

Ist Teil von

• International journal of cancer, 2003-01, Vol.103 (3), p.408-412

Ort / Verlag

New York: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

2003

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Non‐small cell lung cancer (NSCLC) remains a difficult disease to treat and independent prognostic markers other than tumour stage and histology have not emerged. The immune cell content of solid tumours has been associated with tumour regression and at times, tumour progression. The involvement of immune cells in prognosis of NSCLC is poorly described. Poor immune responses within solid tumours have been linked with tumour production of immunosuppressive cytokines. Tumour expression of FasL is thought to disarm responses through the transduction of a death signal in Fas‐expressing T cells. The existence of the ‘tumour counterattack’ in vivo has been questioned. We undertook to measure T cell and macrophage infiltration of the tumour bed in NSCLC and report the association between immune cell content and prognosis in a limited, 3‐year analysis of survival (n = 113). In addition we investigated FasL expression (n = 45). T cells and macrophages were found to frequently infiltrate lung tumours, albeit in small numbers. Generally there were more T cells infiltrating than macrophages. T cell and macrophage numbers were not associated with prognosis. Lung tumours were found not to express FasL, although occasional immune cells surrounding tumour cells were strongly positive. FasL expression was not associated with prognosis in this series. Thus, immune cells infiltrating NSCLC are not capable of suppressing tumour growth, nor are they associated with tumour progression. We report that lung tumours do not express the FasL, and that although some immune cells are FasL positive, this is not a reflection of general immune cell activation. © 2002 Wiley‐Liss, Inc.