Details

Autor(en) / Beteiligte

• Heidecker, Gisela
• Kölch, Walter
• Morrison, Deborah K.
• Rapp, Ulf R.

Titel

The Role of Raf-1 Phosphorylation in Signal Transduction

Ist Teil von

• Advances in Cancer Research, 1992, Vol.58, p.53-73

Ort / Verlag

San Diego, CA: Elsevier Science & Technology

Erscheinungsjahr

1992

Quelle

MEDLINE

Beschreibungen/Notizen

• This chapter discusses the role of Raf-1 phosphorymtion in signal transduction. Raf-1 has a central role in the signal transduction pathways of all growth factors. Its serine/threonine protein kinase activity is increased following the stimulation of most growth factor receptors. The activation is accompanied by phosphorylation on serine and, in some cases, on tyrosine, and threonine residues. When activated, Raf-1 is transiently associated with a signaling complex formed around the activated growth factor receptor that contains several secondary messengers, the commonly found so far being GTPase-activating protein, proteins-phospholipase C-y, and PI-3’ kinase. The composition of the complex varies depending on the growth factor receptor. These findings are reminiscent of the combinatorial nature of transcriptional complexes regulating gene expression. It will be illuminating to see what sites on Raf-1 are modified, and what substrates Raf-1 recognizes and phosphorylates in consequence. Several immediate early genes are regulated by signals transmitted through Raf- 1; eventually the signaling cascade converge in the activation of the cdc2 complex possibly by inducing one of the cell cycle-specific cyclins.