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Nucleoside diphosphate kinase/NM23 expression in breast cancer: Lack of correlation with lymph‐node metastasis
Ist Teil von
International journal of cancer, 1992-02, Vol.50 (4), p.533-538
Ort / Verlag
New York: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
1992
Link zum Volltext
Quelle
Wiley Blackwell Single Titles
Beschreibungen/Notizen
The product of the nm23‐H1 gene, reported to be a meta‐static suppressor gene, was recently identified as the nucleoside diphosphate (NDP) kinase A, and was found to be over‐expressed in several types of malignant tumors as compared with normal tissues. In order to determine whether NDP‐kinase expression serves as a marker for metastatic potential and whether hyperproliferation of neoplastic cells would correlate with expression, we analyzed NDP‐kinase levels and activity by immunohistochemical staining and by an enzymatic assay in 13 benign and 98 malignant breast‐tissue specimens. Our results confirm that NDP‐kinase expression increases in malignant cells of breast carcinomas, but cannot be considered as a biological marker of metastatic dissemination. No correlation was found between NDP‐kinase activity and S phase, taken as an index of cell proliferation. Moreover, no correlation was observed between NDP‐kinase activity and tumor size, histoprognostic index, estrogen receptors or progesterone receptors. The mechanism of over‐expression of NDP in malignant cells and its role in tumor progression remain to be determined.