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Current Opinion in Structural Biology, 2002-12, Vol.12 (6), p.814-821
Ort / Verlag
England: Elsevier Ltd
Erscheinungsjahr
2002
Link zum Volltext
Quelle
Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
Beschreibungen/Notizen
Several common themes have emerged from recent structural and functional studies of proteins involved in the formation of coated vesicles. For example, inositol polyphosphate lipid headgroups are bound specifically by a variety of different domains in ways appropriate to domain function. Another theme is the recognition of short sequence motifs in structureless regions of other coat components, allowing dynamic multicomponent networks to be established.
The assembly of vesicle coats involves an elaborate series of protein-protein and protein-lipid interactions. A combination of structural, biochemical and cell biology is beginning to elucidate the details of the molecular mechanisms.