Details

Autor(en) / Beteiligte

• Hara, Yuji
• Hamada, Mareomi
• Ohtsuka, Tomoaki
• Ogimoto, Akiyoshi
• Saeki, Hideyuki
• Suzuki, Jun
• Matsunaka, Tsuyoshi
• Nakata, Shigeru
• Shigematsu, Yuji

Titel

Use of Thallium-201 Myocardial Scintigraphy for the Prediction of the Response to β-Blocker Therapy in Patients With Dilated Cardiomyopathy

Ist Teil von

• Circulation Journal, 2002, Vol.66(12), pp.1139-1143

Ort / Verlag

Kyoto: The Japanese Circulation Society

Erscheinungsjahr

2002

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• This study was performed to evaluate whether thallium-201 myocardial scintigraphy (Tl-201) and iodine-123-metaiodobenzylguanidine (MIBG) myocardial scintigraphy could predict the usefulness of β-blocker therapy in patients with dilated cardiomyopathy (DCM). Tl-201 and MIBG were performed in 47 patients before β-blocker therapy. Patients were classified into group A, if their cardiac function improved, and group B, whose function remained unchanged. Two types of extent score (ES) by Tl-201 were proposed to quantitate myocardial damage, mean - 2SD (ES-2) and mean - 3SD (ES-3). The ES difference between ES-2 and ES-3 was calculated, and according to ES and ES difference, DCM cases were classified into 3 groups: mild-defect type (mild-type), moderate-defect type (moderate-type) and severe-defect type (severe-type). The heart-to-mediastinum (H/M) MIBG uptake ratio was evaluated, and the percent washout ratio of myocardial MIBG was obtained from these data. Group A comprised 18 mild-type, 14 moderate-type and 1 severe-type cases, and group B comprised 5 mild-type, 4 moderate-type and 5 severe-type cases. A significant relation was observed between the defect type on Tl-201 and the response to β-blocker therapy (p=0.0090). Both H/M MIBG uptake ratios and washout ratio were not significantly different in the 2 groups. Tl-201 may be useful for predicting the response to β-blocker therapy in patients with DCM. (Circ J 2002; 66: 1139 - 1143)