Current Opinion in Chemical Biology, 2002-12, Vol.6 (6), p.872-877
2002
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Details
- Autor(en) / Beteiligte
- Titel
- Mimicry of bioactive peptides via non-natural, sequence-specific peptidomimetic oligomers
- Ist Teil von
- Current Opinion in Chemical Biology, 2002-12, Vol.6 (6), p.872-877
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2002
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- Non-natural, sequence-specific peptidomimetic oligomers are being designed to mimic bioactive peptides, with potential therapeutic application. Cationic, facially amphipathic helical β-peptide oligomers have been developed as magainin mimetics. Non-natural mimics of HIV-Tat protein, lung surfactant proteins, collagen, and somatostatin are also being developed. Pseudo-tertiary structure in β-peptides and peptoids may herald the creation of entirely artificial proteins. Recent advances in bioactive peptide mimicry by various non-natural, sequence-specific peptidomimetic oligomers are reviewed, including mimics of antibacterial magainin peptides, HIV-1 Tat and somatostatin.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1367-5931eISSN: 1879-0402DOI: 10.1016/S1367-5931(02)00385-XTitel-ID: cdi_proquest_miscellaneous_72757840
- Format
- –
- Schlagworte
- Amino Acid Sequence, Anti-Bacterial Agents - chemistry, Anti-Bacterial Agents - pharmacology, Anti-HIV Agents - chemistry, Anti-HIV Agents - pharmacology, Antimicrobial Cationic Peptides - chemistry, Antimicrobial Cationic Peptides - pharmacology, beta-peptide, Biomimetic Materials - chemistry, Biomimetic Materials - pharmacology, biomimicry, collagen, Drug Design, foldamer, Gene Products, tat - chemistry, Gene Products, tat - metabolism, Humans, lung surfactant, MHC-II, Molecular Sequence Data, Oligopeptides - chemistry, Oligopeptides - pharmacology, peptidomimetic, peptoid, Protein Structure, Secondary, Protein Structure, Tertiary, pseudopeptide, Tat