Pharmacological research, 1991-12, Vol.24 (4), p.395-405
1991
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- Autor(en) / Beteiligte
- Titel
- A decrease in brain catecholamines prevents oxiracetam antagonism of the effects of scopolamine on memory and brain acetylcholine
- Ist Teil von
- Pharmacological research, 1991-12, Vol.24 (4), p.395-405
- Ort / Verlag
- London: Elsevier Ltd
- Erscheinungsjahr
- 1991
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- The effect of oxiracetam on passive avoidance conditioned response and acetylcholine (ACh) levels in rats with selective lesions of the central monoaminergic pathways was investigated. The lesions were followed by a marked decrease in cortical serotonin (−88%), noradrenaline (−54%) and striatal dopamine (−57%) levels, while neither the performance of a passive avoidance conditioned response nor brain ACh levels were affected. Scopolamine (hyoscine) administration (0.63 mg/kg, s.c.) to lesioned rats exerted the expected amnesic effect, associated with a decrease in hippocampal, cortical and striatal ACh levels. In the rats with degeneration of dopaminergic and noradrenergic but not serotoninergic pathways, oxiracetam (50 and 100 mg/kg, s.c.) was unable to prevent both amnesia and the decrease in brain ACh levels caused by scopolamine. The effect of oxiracetam was prevented by haloperidol (0.2 mg/kg, s.c.). Our findings support the hypothesis that an interaction between monoaminergic and cholinergic neurotransmitter systems may be involved in the actions of nootropic drugs on cognitive functions.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1043-6618eISSN: 1096-1186DOI: 10.1016/1043-6618(91)90044-XTitel-ID: cdi_proquest_miscellaneous_72701710
- Format
- –
- Schlagworte
- acetylcholine, Acetylcholine - metabolism, Animals, Avoidance Learning - drug effects, Biological and medical sciences, Brain - drug effects, Brain - metabolism, Catecholamines - metabolism, Cerebral Cortex - metabolism, Conditioning (Psychology), Corpus Striatum - metabolism, dopamine, Dopamine - metabolism, Haloperidol - pharmacology, Hippocampus - metabolism, Male, Medical sciences, Memory - drug effects, Neuropharmacology, noradrenaline, Norepinephrine - metabolism, oxiracetam, passive avoidance, Pharmacology. Drug treatments, Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease), Psychology. Psychoanalysis. Psychiatry, Psychopharmacology, Psychotropic Drugs - pharmacology, Pyrrolidines - pharmacology, Rats, Rats, Inbred Strains, Scopolamine Hydrobromide - antagonists & inhibitors, Serotonin - metabolism, Substantia Nigra - metabolism