UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 11 von 143
Datensatz exportieren als...
BibTeX
Impact of parental relationships in maximum lod score affected sib-pair method
Genetic epidemiology, 2002-11, Vol.23 (4), p.413-425
Leutenegger, Anne-Louise
Génin, Emmanuelle
Thompson, Elizabeth A.
Clerget-Darpoux, Françoise
2002
Details
Autor(en) / Beteiligte
Leutenegger, Anne-Louise
Génin, Emmanuelle
Thompson, Elizabeth A.
Clerget-Darpoux, Françoise
Titel
Impact of parental relationships in maximum lod score affected sib-pair method
Ist Teil von
Genetic epidemiology, 2002-11, Vol.23 (4), p.413-425
Ort / Verlag
New York: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2002
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
Many studies are done in small isolated populations and populations where marriages between relatives are encouraged. In this paper, we point out some problems with applying the maximum lod score (MLS) method (Risch, [1990] Am. J. Hum. Genet. 46:242–253) in these populations where relationships exist between the two parents of the affected sib‐pairs. Characterizing the parental relationships by the kinship coefficient between the parents (f), the maternal inbreeding coefficient (αm, and the paternal inbreeding coefficient (αp), we explored the relationship between the identity by descent (IBD) vector expected under the null hypothesis of no linkage and these quantities. We find that the expected IBD vector is no longer (0.25, 0.5, 0.25) when f, αm, and αp differ from zero. In addition, the expected IBD vector does not always follow the triangle constraints recommended by Holmans ([1993] Am. J. Hum. Genet. 52:362–374). So the classically used MLS statistic needs to be adapted to the presence of parental relationships. We modified the software GENEHUNTER (Kruglyak et al. [1996] Am. J. Hum. Genet. 58: 1347–1363) to do so. Indeed, the current version of the software does not compute the likelihood properly under the null hypothesis. We studied the adapted statistic by simulating data on three different family structures: (1) parents are double first cousins (f=0.125, αm=αp=0), (2) each parent is the offspring of first cousins (f=0, αm=αp=0.0625), and (3) parents are related as in the pedigree from Goddard et al. ([1996] Am. J. Hum. Genet. 58:1286–1302) (f=0.109, αm=αp=0.0625). The appropriate threshold needs to be derived for each case in order to get the correct type I error. And using the classical statistic in the presence of both parental kinship and parental inbreeding almost always leads to false conclusions. Genet. Epidemol. 23:413–425, 2002. © 2002 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0741-0395
eISSN: 1098-2272
DOI: 10.1002/gepi.10190
Titel-ID: cdi_proquest_miscellaneous_72680708
Format
–
Schlagworte
affected sib-pair method
,
Biological and medical sciences
,
Computer Simulation
,
Consanguinity
,
Fundamental and applied biological sciences. Psychology
,
Genetics of eukaryotes. Biological and molecular evolution
,
Human
,
Humans
,
identity by descent
,
inbreeding
,
kinship
,
Lod Score
,
Models, Genetic
,
Nuclear Family
,
Pedigree
,
Population genetics, reproduction patterns
,
Software
,
triangle constraints
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX