Neuroscience letters, 1991-10, Vol.132 (1), p.11-15
1991
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Details
- Autor(en) / Beteiligte
- Titel
- Distribution of angiotensin II receptor subtypes in rat brain nuclei
- Ist Teil von
- Neuroscience letters, 1991-10, Vol.132 (1), p.11-15
- Ort / Verlag
- Ireland: Elsevier Ireland Ltd
- Erscheinungsjahr
- 1991
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- Angiotensin II (ANG II) receptor subtypes in rat brain were characterized and quantified by competitive radioligand binding using [ 125I]Sar 1Ile 8angiotensin II ([ 125I]sarilesin) as a tracer and ANG II, sarilesin and the subtype selective ligands DuP 753 (AT 1) and CGP 42112A (AT 2) as competitors. The distribution of AT 1 and AT 2 receptors was determined in midbrain, brainstem, hypothalamus as well as in individual hypothalamic and periventricular nuclei. Whereas in midbrain and brainstem the AT 1: AT 2 ratio was 40%: 60% and 70%: 30% respectively, the AT 1 receptors were by far predominant in hypothalamus and in the nuclei investigated. Interestingly, we found that approximately 25% of the ANG II receptors in hypothalamus did not bind DuP 753 even at 0.1 mM. These sites which bind CGP 42112A, ANG II and sarilesin may represent a third ANG II receptor subtype.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0304-3940eISSN: 1872-7972DOI: 10.1016/0304-3940(91)90420-XTitel-ID: cdi_proquest_miscellaneous_72658267
- Format
- –
- Schlagworte
- Angiotensin II, Angiotensin II - metabolism, Angiotensin II receptor subtype, Animals, Binding, Competitive, Biphenyl Compounds - metabolism, Biphenyl Compounds - pharmacology, Brain - metabolism, Brain Stem - metabolism, CGP 42112A, DuP 753, Hypothalamus - metabolism, Imidazoles - metabolism, Imidazoles - pharmacology, Iodine Radioisotopes, Losartan, Male, Mesencephalon - metabolism, Oligopeptides - metabolism, Oligopeptides - pharmacology, Organ Specificity, Radioligand Assay, Rat brain nucleus, Rats, Rats, Inbred Strains, Receptor ligand binding, Receptors, Angiotensin - analysis, Receptors, Angiotensin - metabolism, Saralasin - metabolism, Saralasin - pharmacology, Tetrazoles - metabolism, Tetrazoles - pharmacology