Details

Autor(en) / Beteiligte

• Park, Y K
• Hann, S K
• Cho, M Y
• Kim, H J
• Shim, S C
• Choi, S J
• Yun, M H

Titel

Study of the skin concentrations after administration of the various phototoxic drugs

Ist Teil von

• Yonsei medical journal, 1991-09, Vol.32 (3), p.231-236

Ort / Verlag

Korea (South)

Erscheinungsjahr

1991

Quelle

MEDLINE

Beschreibungen/Notizen

• The skin concentrations of 8-methoxypsoralen (8-MOP), 5-methoxypsoralen (5-MOP), and 4, 5', 8-trimethylpsoralen (TMP) were studied in the guinea pig following oral administration and bathing. The skin concentration of phototoxic drugs after oral administration peaked at 1.5 hours, and the concentration of 8-MOP was 3.5 times greater than that of 5-MOP. The skin concentration of TMP was not detected in our study (limit of sensitivity 5ng/ml). The skin concentrations of phototoxic drug after bathing decreased in the order of 5-MOP, TMP, and 8-MOP.