Details

Autor(en) / Beteiligte

• Boivin, Guy
• Abed, Yacine
• Pelletier, Gilles
• Ruel, Louisette
• Moisan, Danielle
• Côté, Stéphanie
• Peret, Teresa C. T.
• Erdman, Dean D.
• Anderson, Larry J.

Titel

Virological Features and Clinical Manifestations Associated with Human Metapneumovirus: A New Paramyxovirus Responsible for Acute Respiratory-Tract Infections in All Age Groups

Ist Teil von

• The Journal of infectious diseases, 2002-11, Vol.186 (9), p.1330-1334

Ort / Verlag

Chicago, IL: The University of Chicago Press

Erscheinungsjahr

2002

Link zum Volltext

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• The virological features and clinical findings associated with the new human metapneumovirus (HMPV) were examined retrospectively in Canadian patients hospitalized for various respiratory conditions since 1993. Thirty-eight previously unidentified respiratory viruses isolated from rhesus monkey kindey (LLC-MK2) cells were found to be positive for HMPV by reverse-transcription polymerase chain reaction, and those strains clustered in 2 phylogenetic groups. Children aged <5 years and elderly subjects aged >65 years represented 35.1% and 45.9% of the HMPV-infected cases, respectively. In hospitalized children, the most frequent diagnoses were pneumonitis (66.7%) and bronchiolitis (58.3%), whereas bronchitis and/or bronchospasm (60%) and pneumonitis (40%) were most commonly seen in elderly subjects. Of the 15 patients with pneumonitis, 4 (26.7%) had immunosuppressive conditions and 6 (40%) were infants aged <15 months. These findings suggest that HMPV can be associated with severe lower-respiratory-tract infections in very young children, the elderly, and immunocompromised patients