Details

Autor(en) / Beteiligte

• KHAN, S. G
• RIZVI, R. Y
• HADI, S. M
• RAHMANN, Q

Titel

Influence of silicic acid on in vitro depurination of DNA

Ist Teil von

• Bulletin of environmental contamination and toxicology, 1991-09, Vol.47 (3), p.342-349

Ort / Verlag

New York, NY: Springer-Verlag

Erscheinungsjahr

1991

Quelle

SpringerLINK Contemporary (Konsortium Baden-Württemberg)

Beschreibungen/Notizen

• Silicic acid dissolved from asbestos is considered responsible for some of the pathological responses associated with asbestos toxicity, and an exchange between silicic acid and phosphoric acid in DNA has been suggested. In view of the involvement of the depurination process in various cellular mechanisms of DNA repair, the influence of silicic acid on in vitro depurination of DNA was studied using calf thymus DNA. Silicic acid decreased the rate of heat depurination of DNA in vitro, suggesting the possibility of its reaction with polynucleotides.