Hearing research, 1991-11, Vol.56 (1-2), p.168-172
1991
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Details
- Autor(en) / Beteiligte
- Titel
- Cellular localization of rat Isk protein in the stria vascularis by immunohistochemical observation
- Ist Teil von
- Hearing research, 1991-11, Vol.56 (1-2), p.168-172
- Ort / Verlag
- Amsterdam: Elsevier
- Erscheinungsjahr
- 1991
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- A novel rat membrane protein, termed Isk protein, that exhibits a voltage-dependent potassium channel activity was first reported through molecular cloning combined with an electrophysiological assay (Takumi et al., 1988). In the present study, we made an attempt to identify the cellular localization of the rat Isk protein in the stria vascularis using two types of antibodies that specifically react with the distinct parts of the rat Isk protein. Immunohistochemical analysis showed that the rat Isk protein was present only on the endolymphatic surface of the marginal cell. The possibility that the Isk protein is involved in potassium permeation in the luminal membrane of the marginal cell will be also discussed.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0378-5955eISSN: 1878-5891DOI: 10.1016/0378-5955(91)90166-7Titel-ID: cdi_proquest_miscellaneous_72584985
- Format
- –
- Schlagworte
- Amino Acid Sequence, Animals, Biological and medical sciences, Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation, Fundamental and applied biological sciences. Psychology, Immunohistochemistry, Male, Membrane Proteins - chemistry, Membrane Proteins - metabolism, Molecular Sequence Data, Potassium Channels - metabolism, Potassium Channels, Voltage-Gated, Rats, Rats, Inbred Strains, Sodium-Potassium-Exchanging ATPase - metabolism, Sodium-Potassium-Exchanging ATPase - physiology, Stria Vascularis - metabolism, Vertebrates: nervous system and sense organs