Details

Autor(en) / Beteiligte

• FLORENCE, Geneviève
• BONNIER, Richard
• PLAGNES, Didier
• PIERARD, Christophe
• SATABIN, Pascale
• PERES, Michel
• LAGARDE, Didier

Titel

Effect of modafinil on cerebral blood flow of anaesthetised rats : Comparison with amphetamine

Ist Teil von

• Experimental brain research, 2000-12, Vol.135 (4), p.552-556

Ort / Verlag

Berlin: Springer

Erscheinungsjahr

2000

Quelle

SpringerLINK Contemporary (Konsortium Baden-Württemberg)

Beschreibungen/Notizen

• This experiment compares the cardio- and cerebrovascular effects of modafinil and amphetamine administered to rats. Injections of 300 mg/kg and 600 mg/kg modafinil i.p. had no major effect. In contrast, injection of D-amphetamine sulfate (5 mg/kg i.v.) induced a long-lasting rise in heart rate and in mean arterial blood pressure (MABP). Amphetamine administration also elicited a 70-min-long increase in cortical cerebral blood flow which was proportional to the increase in MABP. We conclude that, contrary to amphetamine, modafinil has no effect on perfusion in the cerebral cortex of anaesthetised rats.