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Inhibition of alpha-glucosidase and amylase by luteolin, a flavonoid
Ist Teil von
Bioscience, biotechnology, and biochemistry, 2000-11, Vol.64 (11), p.2458-2461
Ort / Verlag
Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry
Erscheinungsjahr
2000
Quelle
Free E-Journal (出版社公開部分のみ)
Beschreibungen/Notizen
Twenty-one naturally occurring flavonoids were tested for inhibitory activities against alpha-glucosidase (EC 3.2.1.20) and alpha-amylase (EC 3.2.1.1). Luteolin, amentoflavone, luteolin 7-O-glucoside, and daidzein were the strongest inhibitors among the compounds tested. Luteolin inhibited alpha-glucosidase by 36% at the concentration of 0.5 mg/ml and was stronger than acarbose, the most widely prescribed drug, in inhibitory potency, suggesting that it has the possibility to effectively suppress postprandial hyperglycemia in patients with non-insulin dependent diabetes mellitus. Luteolin also inhibited alpha-amylase effectively although it was less potent than acarbose. The clinical value of luteolin needs to be further evaluated.