Bioscience, biotechnology, and biochemistry, 2000-11, Vol.64 (11), p.2458-2461
2000
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Details
- Autor(en) / Beteiligte
- Titel
- Inhibition of alpha-glucosidase and amylase by luteolin, a flavonoid
- Ist Teil von
- Bioscience, biotechnology, and biochemistry, 2000-11, Vol.64 (11), p.2458-2461
- Ort / Verlag
- Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry
- Erscheinungsjahr
- 2000
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Twenty-one naturally occurring flavonoids were tested for inhibitory activities against alpha-glucosidase (EC 3.2.1.20) and alpha-amylase (EC 3.2.1.1). Luteolin, amentoflavone, luteolin 7-O-glucoside, and daidzein were the strongest inhibitors among the compounds tested. Luteolin inhibited alpha-glucosidase by 36% at the concentration of 0.5 mg/ml and was stronger than acarbose, the most widely prescribed drug, in inhibitory potency, suggesting that it has the possibility to effectively suppress postprandial hyperglycemia in patients with non-insulin dependent diabetes mellitus. Luteolin also inhibited alpha-amylase effectively although it was less potent than acarbose. The clinical value of luteolin needs to be further evaluated.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0916-8451eISSN: 1347-6947DOI: 10.1271/bbb.64.2458Titel-ID: cdi_proquest_miscellaneous_72527029
- Format
- –
- Schlagworte
- ALPHA GLUCOSIDASE, alpha-amylase, alpha-glucosidase inhibitor, alpha-Glucosidases - metabolism, Amylases - antagonists & inhibitors, Amylases - metabolism, Biflavonoids, Biological and medical sciences, DIABETES, ENZYME INHIBITORS, Enzyme Inhibitors - pharmacology, Enzyme Inhibitors - therapeutic use, FLAVONOIDS, Flavonoids - pharmacology, Flavonoids - therapeutic use, Glucosides - pharmacology, Glycoside Hydrolase Inhibitors, Hormones. Endocrine system, Humans, Hyperglycemia - drug therapy, Isoflavones - pharmacology, Luteolin, Medical sciences, Pharmacology. Drug treatments