Details

Autor(en) / Beteiligte

• Granowitz, E.V.
• Poutsiaka, D.D.
• Cannon, J.G.
• Wolff, S.M.
• Dinarello, C.A.
• Santos, A.A.
• Wilmore, D.W.

Titel

Production of interleukin-1-receptor antagonist during experimental endotoxaemia

Ist Teil von

• The Lancet (British edition), 1991-12, Vol.338 (8780), p.1423-1424

Ort / Verlag

London: Elsevier Ltd

Erscheinungsjahr

1991

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Interleukin-1 (IL-1) has been implicated in the pathogenesis of sepsis. IL-1-receptor antagonist (IL-1ra) is a naturally occurring inhibitor of IL-1 activity that competes with IL-1 for occupancy of cell-surface receptors but possesses no agonist activity. We induced endotoxaemia in 9 healthy human volunteers by injection of Escherichia coliendotoxin, and measured plasma concentrations of IL-1 and IL-1ra by radioimmunoassay during the next 24 h. Peak plasma concentrations of IL-1ra were about a hundred-fold greater than those of IL-1β. No IL-1 or IL-1ra were detectable in the plasma of 4 volunteers injected with saline. Our results suggest that the predominant natural response to endotoxin in man is the production of antagonist rather than agonist.