Details

Autor(en) / Beteiligte

• Guo, Chun
• White, Peter S.
• Hogarty, Michael D.
• Brodeur, Garrett M.
• Gerbing, Robert
• Stram, Daniel O.
• Maris, John M.

Titel

Deletion of 11q23 is a frequent event in the evolution of MYCN single-copy high-risk neuroblastomas

Ist Teil von

• Medical and pediatric oncology, 2000-12, Vol.35 (6), p.544-546

Ort / Verlag

New York: John Wiley & Sons, Inc

Erscheinungsjahr

2000

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Background Deletions of the long arm of chromosome 11 are frequently identified in human neuroblastomas. Procedure We screened 394 primary neuroblastomas and 52 tumor‐derived cell lines with a panel of 11q and 11p polymorphic markers to determine the frequency of chromosome 11 allelic deletion, and to differentiate partial deletions of chromosome 11q (unb[11q] LOH) from whole chromosome loss. Results Allelic deletion occurred most frequently at cytogenetic band 11q23 and was detected in 161 primary neuroblastomas (41%) and 18 cell lines (35%). Eighty‐seven tumors (22%) had unb[11q] LOH with a heterogeneous distribution of deletion breakpoints. Unb[11q] LOH was highly correlated with age > 1 year at diagnosis (P = 0.008), stage 4 disease (P = 0.001), unfavorable Shimada histopathology (P < 0.001), and assignment to a high‐risk therapeutic protocol (P < 0.001), and was inversely correlated with MYCN amplification (P = 0.018). Patients whose tumors showed unb[11q] LOH were less likely to survive (P < 0.001), but there was only a trend towards an independent prognostic influence in multivariate analyses. Conclusions Thus, structural rearrangements resulting in unb[11q] LOH commonly occur during the malignant evolution of high‐risk neuroblastomas with single‐copy MYCN. Med. Pediatr. Oncol. 35: 544–546, 2000. © 2000 Wiley‐Liss, Inc.