Details

Autor(en) / Beteiligte

• Behrens, Stephan
• Spengos, Konstantinos
• Daffertshofer, Michael
• Schroeck, Helmut
• Dempfle, Carl E
• Hennerici, Michael

Titel

Transcranial ultrasound-improved thrombolysis: diagnostic vs. therapeutic ultrasound

Ist Teil von

• Ultrasound in medicine & biology, 2001-12, Vol.27 (12), p.1683-1689

Ort / Verlag

Amsterdam: Elsevier Inc

Erscheinungsjahr

2001

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• Success of stroke treatment with rt-PA depends on rapid vessel recanalization. Enzymatic thrombolysis may be enhanced by additional transcranial application of ultrasound (US). We investigated this novel technique using a 185-kHz probe and compared it to standard diagnostic US. In vitro studies were performed in a continuous pressure tubing system. Clots were placed in a postmortem skull and treated with rt-PA together with or without transtemporal 185-kHz US insonation (2W/cm 2) and in comparison to 1-MHz diagnostic US (0.5 W/cm 2). Recanalization time was significantly ( p < 0.01) shorter in the 185-kHz (14.1 min) and 1-MHz (17.1 min) US rt-PA treatment group compared to rt-PA treatment alone (29.3 min.). Flow rate was significantly higher ( p < 0.025) and increased faster in the combined treatment group with rt-PA + 185-kHz US compared to rt-PA + 1-MHz US. We investigated the blood-brain barrier in rats after 90-min exposure time of the brain with 185-kHz US, but no damage was observed. Results suggest efficacy and safety of the 185-kHz transducer, which is superior to diagnostic US. Such a novel US probe may be able to optimize thrombolytic stroke treatment. (E-mail: hennerici@neuro.ma.uni-heidelberg.de)