Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Interactions between Mycobacterium leprae and simian immunodeficiency virus (SIV) in rhesus monkeys
Ist Teil von
Journal of medical primatology, 2000-08, Vol.29 (3-4), p.259-267
Ort / Verlag
Copenhagen: Munksgaard
Erscheinungsjahr
2000
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
Groups of rhesus monkeys were inoculated with: 1) simian immunodeficiency virus (SIV)B670 alone; 2) Mycobacterium
leprae alone; 3) SIV plus M. leprae on the same day; and 4)
M. leprae 2 weeks after SIV. Animals were monitored at intervals for
virus loads, antibody responses to M. leprae glycolipid antigens
and to SIV Gp120, T‐cell CD4+ and CD4+CD29+ subset percentages, leprosy
and acquired immunodeficiency syndrome (AIDS) clinical symptoms. Five out
of six animals developed leprosy in each co‐inoculated group, compared to
one out of six in the M. leprae‐only‐inoculated group, indicating
that M. leprae/SIV co‐infection increases the susceptibility to
leprosy, regardless of the timing of the two infections. Animals in the
co‐infected group that received M. leprae 2 weeks after SIV had a
significantly slower rate of AIDS progression and long‐term survival was
significantly greater (three out of six) compared to the group inoculated
with SIV alone (zero out of seven). All M. leprae‐only‐inoculated
animals (six out of six) survived. Post‐SIV‐inoculation, a rapid decrease
in the percentages of CD4+ and CD4+CD29+ T‐cells was observed in the
SIV‐only‐inoculated group that was significantly blocked by
co‐inoculation with M. leprae 2 weeks after SIV, but not by SIV on
the same day. The virus load set point was increased by approximately two
logs in the group inoculated with M. leprae and SIV on the same
day compared to SIV 2 weeks prior to M. leprae or the
SIV‐only‐inoculated group. The results indicate that M. leprae,
inoculated 2 weeks after SIV, decreased the pathogenicity of SIV compared
to inoculation of M. leprae and SIV on the same day or SIV alone.
The decreased pathogenicity correlated with a diminished loss of CD4+ and
CD4+CD29+ T‐cell subsets in the group inoculated with M. leprae 2
weeks after SIV compared to the group inoculated with SIV alone. IgG
antibody responses to M. leprae‐specific cell wall phenolic
glycolipid‐I antigen were inhibited by 2‐week‐prior or same‐day SIV
co‐inoculation compared to M. leprae‐only inoculated animals. The
IgG anti‐lipoarabinomannan antibody response was enhanced in the group
inoculated with M. leprae and SIV on the same day compared to the
groups inoculated with M. leprae alone or SIV 2 weeks prior to
M. leprae. Antibody responses to SIV Gp120 antigen were unimpaired
in both co‐inoculated groups compared to SIV‐only‐inoculated groups. The
antibody results show that the immune responses to SIV and M.
leprae are interrelated in SIV/M. leprae co‐infected animals.