Details

Autor(en) / Beteiligte

• Denzler, Karen L
• Farmer, Steven C
• Crosby, Jeffrey R
• Borchers, Michael
• Cieslewicz, Grzegorz
• Larson, Kirsten A
• Cormier-Regard, Stephania
• Lee, Nancy A
• Lee, James J

Titel

Eosinophil Major Basic Protein-1 Does Not Contribute to Allergen-Induced Airway Pathologies in Mouse Models of Asthma

Ist Teil von

• The Journal of immunology (1950), 2000-11, Vol.165 (10), p.5509-5517

Ort / Verlag

United States: Am Assoc Immnol

Erscheinungsjahr

2000

Quelle

MEDLINE

Beschreibungen/Notizen

• The relationship between eosinophils and the development of Ag-induced pulmonary pathologies, including airway hyper-responsiveness, was investigated using mice deficient for the secondary granule component, major basic protein-1 (mMBP-1). The loss of mMBP-1 had no effect on OVA-induced airway histopathologies or inflammatory cell recruitment. Lung function measurements of knockout mice demonstrated a generalized hyporeactivity to methacholine-induced airflow changes (relative to wild type); however, this baseline phenotype was observable only with methacholine; no relative airflow changes were observed in response to another nonspecific stimulus (serotonin). Moreover, OVA sensitization/aerosol challenge of wild-type and mMBP-1(-/-) mice resulted in identical dose-response changes to either methacholine or serotonin. Thus, the airway hyper-responsiveness in murine models of asthma occurs in the absence of mMBP-1.