Details

Autor(en) / Beteiligte

• Cherny, Stacey S.
• Abecasis, Gonçalo R.
• Cookson, William O.C.
• Sham, Pak C.
• Cardon, Lon R.

Titel

The Effect of Genotype and Pedigree Error on Linkage Analysis: Analysis of Three Asthma Genome Scans

Ist Teil von

• Genetic epidemiology, 2001, Vol.21 (S1), p.S117-S122

Ort / Verlag

United States

Erscheinungsjahr

2001

Link zum Volltext

Quelle

Wiley Online Library Journals【キャンパス外アクセス可】

Beschreibungen/Notizen

• The effects of genotype and relationship errors on linkage results arc evaluated in three of the Genetic Analysis Workshop 12 asthma genome scans. A number of errors are detected in the samples. While the evidence for linkage is not striking in any data set with or without error, in some cases the difference in test statistic could support different conclusions. The results provide empirical evidence for the predicted effects of genotype and relationship error and highlight the need for rigorous detection and elimination of data error in complex trait studies. © 2001 Wiley‐Liss, Inc.