Peptides (New York, N.Y. : 1980), 2001-12, Vol.22 (12), p.2119-2126
2001
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Details
- Autor(en) / Beteiligte
- Titel
- Effects of peripheral and central administration of GHRH on feeding in aging LOU rats
- Ist Teil von
- Peptides (New York, N.Y. : 1980), 2001-12, Vol.22 (12), p.2119-2126
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2001
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- In aging LOU rats, a decreased protein intake is restored by GH administration. To study the contribution of GHRH to macronutrient selection, hGHRH [1–29]NH 2 was administered sc. (1 mg/kg B.W./day/14 days) or icv. (4 and 40 pmol/rat) to 11-, 19-, 24- and 28-month-old rats. Sc. administration induced a decreased food and lipid intakes from 24 months of age and a transient stimulation of protein intake in 19-month-old and older low protein eaters (<10% protein/total intake). Icv. administration induced decreased food and lipid intakes in all age groups. These results suggest that GHRH may regulate feeding through pituitary and/or hypothalamic GHRH receptor mechanisms.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0196-9781eISSN: 1873-5169DOI: 10.1016/S0196-9781(01)00560-5Titel-ID: cdi_proquest_miscellaneous_72395531
- Format
- –
- Schlagworte
- Aging, Animals, Dietary Proteins - administration & dosage, Energy Intake, Feeding behavior, Feeding Behavior - drug effects, Female, Growth hormone-releasing hormone, Growth Hormone-Releasing Hormone - administration & dosage, Growth Hormone-Releasing Hormone - pharmacology, Insulin-Like Growth Factor I - metabolism, Lipid intake, LOU/C/jall rats, Male, Protein intake, Radioimmunoassay, Rats